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Association of DLA ‐ DQB 1 alleles with exocrine pancreatic insufficiency in P embroke W elsh C orgis
Author(s) -
Evans J. M.,
Tsai K. L.,
StarrMoss A. N.,
Steiner J. M.,
Clark L. A.
Publication year - 2015
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12317
Subject(s) - allele , biology , haplotype , genetics , odds ratio , medicine , pathogenesis , gastroenterology , endocrinology , immunology , gene
Summary Exocrine pancreatic insufficiency ( EPI ) is a digestive disorder resulting from the insufficient secretion of enzymes from the pancreas. In dogs, this condition is often attributed to pancreatic acinar atrophy, wherein the enzyme‐producing acinar cells are believed to be destroyed through an autoimmune process. Although EPI affects many diverse breeds, to date, molecular studies have been limited to the G erman S hepherd dog. A recent study of major histocompatibility genes in diseased and healthy G erman S hepherd dogs identified both risk and protective haplotypes. Herein, we genotyped DLA ‐ DQB 1 in P embroke W elsh C orgis to determine whether dog leukocyte antigen alleles contribute to the pathogenesis of EPI across dog breeds. We evaluated 14 affected and 43 control P embroke W elsh C orgis, which were selected based on an age of onset similar to G erman S hepherd dogs. We identified one protective allele (odds ratio = 0.13, P ‐value = 0.044) and one risk allele (odds ratio = 3.8, P ‐value = 0.047). As in G erman S hepherd dogs, the risk allele is a duplication of DLA ‐ DQB 1 (alleles DQB 1*013:03 and 017:01 ); however, P embroke W elsh C orgis have acquired a single polymorphism on DQB 1*017:01 . Thus, the DLA ‐ DQB 1 duplication is a risk allele for EPI in at least two breeds.