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Genome‐wide association study for jumping performances in F rench sport horses
Author(s) -
Brard S.,
Ricard A.
Publication year - 2015
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12245
Subject(s) - biology , jumping , genetics , genome wide association study , association (psychology) , genome , computational biology , gene , genotype , single nucleotide polymorphism , physiology , philosophy , epistemology
Summary A genome‐wide association study was performed to identify single nucleotide polymorphisms ( SNP s) associated with jumping performances of warmbloods in France. The 999 horses included in the study for jumping performances were sport horses [mostly S elle F rançais (68%), A nglo‐ A rabians (13%) and horses from the other E uropean studbooks]. Horses were genotyped using the I llumina E quine SNP 50 B ead C hip. Of the 54 602 SNP s available on this chip, 44 424 were retained after quality testing. Phenotypes were obtained by deregressing official breeding values for jumping competitions to use all available information, that is, the performances of each horse as well as those of its relatives. Two models were used to test the effects of the genotypes on deregressed phenotypes: a single‐marker mixed model and a haplotype‐based mixed model (significant: P < 1 E ‐05; suggestive: P < 1 E ‐04). Both models included a polygenic effect to take into account familial structures. For jumping performances, one suggestive quantitative trait locus ( QTL ) located on chromosome 1 ( BIEC 2_31196 and BIEC 2_31198 ) was detected with both models. This QTL explains 0.7% of the phenotypic variance. RYR 2 , a gene encoding a major calcium channel in cardiac muscle in humans and mice, is located 0.55 Mb from this potential QTL .