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Genome‐wide association study identifies quantitative trait loci affecting hematological traits in an F 2 intercross between L andrace and K orean native pigs
Author(s) -
Jung E. J.,
Park H. B.,
Lee J. B.,
Yoo C. K.,
Kim B. M.,
Kim H. I.,
Cho I. C.,
Lim H. T.
Publication year - 2014
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12175
Subject(s) - biology , quantitative trait locus , genome wide association study , genetics , trait , genetic association , korean native , association mapping , gene , single nucleotide polymorphism , genotype , ecology , programming language , computer science
Summary Changes affecting the status of health and robustness can bring about physiological alterations including hematological parameters in swine. To identify quantitative trait loci ( QTL ) associated with eight hematological traits (one leukocyte trait, six erythrocyte traits and one platelet trait), we conducted a genome‐wide association study using the Porcine SNP 60K BeadChip in a resource population derived from an intercross between Landrace and Korean native pigs. A total of 36 740 SNP s from 816 F 2 progeny were analyzed for each blood‐related trait after filtering for quality control. Data were analyzed by the genome‐wide rapid association using mixed model and regression ( GRAMMAR ) approach. A total of 257 significant SNP s ( P < 1.36 × 10 −6 ) on SSC 3, 6, 8, 13 and 17 were identified for blood‐related traits in this study. Interestingly, the genomic region between 17.9 and 130 Mb on SSC 8 was found to be significantly associated with red blood cell, mean corpuscular volume and mean corpuscular hemoglobin. Our results include the identification of five significant SNP s within five candidate genes ( KIT , IL 15, TXK , ARAP 2 and ERG ) for hematopoiesis. Further validation of these identified SNP s could give valuable information for understanding the variation of hematological traits in pigs.