Genome‐wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs | Zendy

Baird A. E. G. | Zendy; Carter S. D. | Zendy; Innes J. F. | Zendy; Ollier W. | Zendy; Short A. | Zendy

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Genome‐wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Author(s) -

Baird A. E. G.,

Carter S. D.,

Innes J. F.,

Ollier W.,

Short A.

Publication year - 2014

Publication title -

animal genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.756

H-Index - 81

eISSN - 1365-2052

pISSN - 0268-9146

DOI - 10.1111/age.12162

Subject(s) - cruciate ligament , genotyping , medicine , genome wide association study , single nucleotide polymorphism , snp , lameness , snp genotyping , biology , genotype , bioinformatics , gene , genetics , anterior cruciate ligament , anatomy , surgery

Summary Cranial cruciate ligament rupture ( CCLR ) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR , we conducted a genome‐wide association study using a canine SNP array in N ewfoundland pedigree dogs with and without CCLR ( n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by S equenom genotyping in a further cohort of N ewfoundlands ( n = 271). The results, particularly SNP s identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR .

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