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Genome‐wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs
Author(s) -
Baird A. E. G.,
Carter S. D.,
Innes J. F.,
Ollier W.,
Short A.
Publication year - 2014
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12162
Subject(s) - cruciate ligament , genotyping , medicine , genome wide association study , single nucleotide polymorphism , snp , lameness , snp genotyping , biology , genotype , bioinformatics , gene , genetics , anterior cruciate ligament , anatomy , surgery
Summary Cranial cruciate ligament rupture ( CCLR ) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR , we conducted a genome‐wide association study using a canine SNP array in N ewfoundland pedigree dogs with and without CCLR ( n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by S equenom genotyping in a further cohort of N ewfoundlands ( n = 271). The results, particularly SNP s identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR .