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Genome‐wide association analysis identifies quantitative trait loci for growth in a L andrace purebred population
Author(s) -
Jung E. J.,
Park H. B.,
Lee J. B.,
Yoo C. K.,
Kim B. M.,
Kim H. I.,
Kim B. W.,
Lim H. T.
Publication year - 2014
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12117
Subject(s) - biology , purebred , quantitative trait locus , genome wide association study , single nucleotide polymorphism , genetics , snp , genetic association , autosome , linkage disequilibrium , candidate gene , population , chromosome , gene , genotype , crossbreed , demography , sociology
Summary Growth‐related traits are complex and economically important in the livestock industry. The aim of this study was to identify quantitative trait loci ( QTL ) and the associated positional candidate genes affecting growth in pigs. A genome‐wide association study ( GWAS ) was performed using the porcine single‐nucleotide polymorphism ( SNP ) 60K bead chip. A mixed‐effects model and linear regression approach were used for the GWAS . The data used in the study included 490 purebred Landrace pigs. All experimental animals were genotyped with 39 438 SNP s located throughout the pig autosomes. We identified a strong association between a SNP marker on chromosome 16 and body weight at 71 days of age ( ALGA 0092396 , P = 5.35 × 10 −9 , Bonferroni adjusted P < 0.05). The SNP marker was located near the genomic region containing IRX 4 , which encodes iroquois homeobox 4. This SNP marker could be useful in the selective breeding program after validating its effect on other populations.