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Hepatic transcriptome profiling identifies differences in expression of genes associated with changes in metabolism and postnatal growth between Hereford and Holstein‐Friesian bulls
Author(s) -
Lisowski Pawel,
Kościuczuk Ewa M.,
Gościk Joanna,
Pierzchała Mariusz,
Rowińska Barbara,
Zwierzchowski Lech
Publication year - 2014
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12116
Subject(s) - biology , igfbp3 , transcriptome , growth hormone receptor , breed , lipid metabolism , gene , gene expression profiling , cd36 , genetics , gene expression , growth hormone , endocrinology , growth factor , hormone , receptor
Summary This study examined liver transcriptomic profiles of cattle distinctly different in meat and milk production capacity. It was performed on bulls of two different genetic backgrounds: Herefords ( H ), a meat breed, and Holstein‐Friesians ( HF ), a dairy breed. Using bovine long oligo‐microarrays and q PCR , we identified 128 genes that are differentially expressed between the two breeds. In H bulls, we observed up‐regulation of genes involved in fatty acid biosynthesis and lipid metabolism ( CD36 , CAT , HSD3B1 , FABP1 , ACAA1 ) and involved in insulin signaling ( INSR , INSIG2 , NR4A1 ) and down‐regulation of genes involved in somatotropic axis signaling ( IGF1 , GHR , IGFBP3 ) as compared to HF. Transcriptome profiling of these two breeds allowed us to pinpoint the transcriptional differences between Holstein and Hereford bulls at hepatic level associated with changes in metabolism and postnatal growth.

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