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Genetic association between NOD 2 polymorphism and infection status by M ycobacterium avium ssp. paratuberculosis in G erman H olstein cattle
Author(s) -
Küpper J. D.,
Brandt H. R.,
Erhardt G.
Publication year - 2014
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12097
Subject(s) - single nucleotide polymorphism , biology , paratuberculosis , snp , allele , genbank , genetics , exon , nod2 , feces , polymorphism (computer science) , gene , genotype , microbiology and biotechnology , mycobacterium , bacteria , immune system , innate immune system
Summary The aim of the study was the analysis of the nucleotide‐binding oligomerization domain containing 2 ( NOD 2, formerly CARD 15 ) as a candidate gene for M ycobacterium avium ssp. paratuberculosis infection in cattle. Eleven SNP s in the NOD 2 gene were identified, and finally, four SNP s were included in a case–control study using 324 G erman H olstein cows tested for paratuberculosis using fecal culture and ELISA . The SNP ( G en B ank) AY 518738S04:g.521 G > A in exon 4 showed a significant association between the fecal culture status of the animals and NOD 2 allele variants. The other three SNP s showed no associations in G erman H olstein cows.