Genetic association between   NOD 2  polymorphism and infection status by   M ycobacterium avium  ssp.  paratuberculosis  in  G erman  H olstein cattle | Zendy

Küpper J. D. | Zendy; Brandt H. R. | Zendy; Erhardt G. | Zendy

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Genetic association between NOD 2 polymorphism and infection status by M ycobacterium avium ssp. paratuberculosis in G erman H olstein cattle

Author(s) -

Küpper J. D.,

Brandt H. R.,

Erhardt G.

Publication year - 2014

Publication title -

animal genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.756

H-Index - 81

eISSN - 1365-2052

pISSN - 0268-9146

DOI - 10.1111/age.12097

Subject(s) - single nucleotide polymorphism , biology , paratuberculosis , snp , allele , genbank , genetics , exon , nod2 , feces , polymorphism (computer science) , gene , genotype , microbiology and biotechnology , mycobacterium , bacteria , immune system , innate immune system

Summary The aim of the study was the analysis of the nucleotide‐binding oligomerization domain containing 2 ( NOD 2, formerly CARD 15 ) as a candidate gene for M ycobacterium avium ssp. paratuberculosis infection in cattle. Eleven SNP s in the NOD 2 gene were identified, and finally, four SNP s were included in a case–control study using 324 G erman H olstein cows tested for paratuberculosis using fecal culture and ELISA . The SNP ( G en B ank) AY 518738S04:g.521 G > A in exon 4 showed a significant association between the fecal culture status of the animals and NOD 2 allele variants. The other three SNP s showed no associations in G erman H olstein cows.

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