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Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in K orean native cattle
Author(s) -
Kim H.,
Lee S. K.,
Hong M. W.,
Park S. R.,
Lee Y. S.,
Kim J. W.,
Lee H. K.,
Jeong D. K.,
Song Y. H.,
Lee S. J.
Publication year - 2013
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12055
Subject(s) - marbled meat , single nucleotide polymorphism , biology , snp , genetics , genotype , bonferroni correction , korean native , hanwoo , beef cattle , polymorphism (computer science) , polymerase chain reaction , gene , zoology , food science , statistics , mathematics
Summary The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor‐kappa B ( NF ‐κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism ( SNP ) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3′‐ UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA , AG , and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.