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Genome‐wide association study of osteochondrosis in the tarsocrural joint of D utch W armblood horses identifies susceptibility loci on chromosomes 3 and 10
Author(s) -
Orr N.,
Hill E. W.,
Gu J.,
Govindarajan P.,
Conroy J.,
Grevenhof E. M.,
Ducro B. J.,
Arendonk J. A. M,
Knaap J. H.,
Weeren P. R.,
MacHugh D. E.,
Ennis S.,
Brama P. A. J.
Publication year - 2013
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12016
Subject(s) - warmblood , osteochondrosis , biology , genetics , genome wide association study , genetic association , horse , population , genotype , single nucleotide polymorphism , anatomy , gene , medicine , paleontology , environmental health
Summary Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome‐wide association study of osteochondrosis using 90 cases and 111 controls from a population of D utch W armblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 ( BIEC 2‐808543; P = 5.03 × 10 −7 ) and chromosome 10 ( BIEC 2‐121323; P = 2.62 × 10 −7 ).