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The role of polymorphism of the IL6 gene in tooth replantation
Author(s) -
Roskamp Liliane,
Trevilatto Paula Cristina,
Souza Cleber Machado,
Ignácio Sergio Aparecido,
Lima Giomo Dieila,
Pereira Thaís Munhoz,
Westphalen Vânia Portela Ditzel
Publication year - 2021
Publication title -
australian endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 34
eISSN - 1747-4477
pISSN - 1329-1947
DOI - 10.1111/aej.12483
Subject(s) - replantation , tooth replantation , dentistry , medicine , resorption , root resorption , surgery
The absence or presence of root resorption on the root surface of a replanted tooth indicates an immune‐inflammatory reaction. Since interleukin‐6 (IL‐6) is considered an inflammatory marker in bone resorption, this study aimed to investigate the association between clinical variables and polymorphisms in IL6 , with the outcome of replanted teeth at 1‐year follow‐up. Altogether, 127 avulsed teeth that were replanted and had their root canals treated were selected for this study. Periapical radiographs were taken after replantation and after 1 year. Real‐time PCR was used to genotype IL6 polymorphisms. Chi‐square and ‘ Z ’ tests were performed to verify the association between genetic variables and the prognosis of replanted teeth ( P < 0.05). An association was observed between the rs2069843 polymorphism of IL6 and the outcome of replanted teeth ( P < 0.05). The rs2069843 polymorphism of IL6 may influence the outcome of avulsed and replanted teeth in the first year post‐trauma.