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Histological assessment of human regenerative endodontic procedures ( REP ) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review
Author(s) -
Digka Anna,
Sakka Dimitra,
Lyroudia Kleoniki
Publication year - 2020
Publication title -
australian endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 34
eISSN - 1747-4477
pISSN - 1329-1947
DOI - 10.1111/aej.12371
Subject(s) - dentistry , pulp (tooth) , medicine , endodontics , pulp necrosis , periodontitis , inclusion and exclusion criteria , cochrane library , endodontic retreatment , regeneration (biology) , permanent teeth , orthodontics , surgery , pathology , root canal , biology , randomized controlled trial , microbiology and biotechnology , alternative medicine
The aim of this study was to systematically review the histological evidence of the neo‐formed tissues inside the root canals of human teeth having previously received regenerative endodontic treatment. An electronic research was performed in the MEDLINE , Web of Science, Scopus and Cochrane Library databases using controlled vocabulary. The retrieved studies were screened by two reviewers according to the predetermined inclusion and extrusion criteria and were full‐text‐evaluated. Research resulted in 160 studies. Among them, twelve fitted the inclusion criteria and were critically appraised. The tissues formed in the root canals of immature human teeth treated with REP indicate repair or a combination of repair and regeneration. Pulp remnants and healthy periapical tissues seem to improve regeneration. The level of available evidence was low. Further clinical studies are needed in order to establish the appropriate treatment protocol related to the pretreatment status of the dental pulp and the periapical tissues.