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Histological analysis of different local haemostatic agents used for periapical surgery: An experimental study with Sprague‐Dawley rats
Author(s) -
MenaÁlvarez Jesús,
QuispeLópez Norberto,
ZubizarretaMacho Álvaro,
RicoRomano Cristina,
RoderoVillanueva Rosa,
FernándezAceñero María Jesús
Publication year - 2019
Publication title -
australian endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 34
eISSN - 1747-4477
pISSN - 1329-1947
DOI - 10.1111/aej.12332
Subject(s) - medicine , dentistry
The aim of the present study was to analyse differences in the tissue response to the different haemostatic agents used for periapical surgery (BloodSTOP iX ® (oxicellulose), Expazen ® (aluminum chloride), calcium sulphate (CS), Gelatamp ® (gelatin sponge) and Hemocor ® (ferric sulphate). Seventy‐two bone defects were made on the calvarium of 36 Sprague‐Dawley rats. The specimens were euthanised at 3, 6 and 12 weeks. Histological analysis revealed a giant cell foreign body reaction against BloodStop iX ® , Gelatamp ® and Hemocor ® . Leukocytes persisted at the surgical bed during the healing process longer as expected with Gelatamp ® (6 weeks) and Hemocor® (12 weeks). We confirmed a generalised delay in bone formation. Calcium sulphate did not cause any foreign body reaction. CS showed excellent results with a high degree of compatibility, there was no inflammatory reaction with this agent after 12 weeks and was not associated with a significant foreign body reaction at any time during the study.