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Effect of ibuprofen on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A meta‐analysis
Author(s) -
Geus Juliana L.,
Wambier Leticia M.,
Boing Thaynara F.,
Loguercio Alessandro D.,
Reis Alessandra
Publication year - 2019
Publication title -
australian endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 34
eISSN - 1747-4477
pISSN - 1329-1947
DOI - 10.1111/aej.12306
Subject(s) - medicine , ibuprofen , inferior alveolar nerve , placebo , anesthesia , pulpitis , cochrane library , meta analysis , premedication , nerve block , confidence interval , mandibular nerve , relative risk , dentistry , pharmacology , molar , alternative medicine , pulp (tooth) , pathology
The aim of this study was to compare preventive ibuprofen administration to placebo on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis. A search was performed in PubMed, Scopus, Web of Science, LILACS , BBO , Cochrane Library, SIGLE , and grey literature. The risk of bias was evaluated through the Cochrane Collaboration's tool. The quality of evidence was assessed using the GRADE approach. Only seven studies remained for the meta‐analysis. Administering ibuprofen before anaesthesia increased the success rate of injectable anaesthesia ( RR = 1.79; 95% confidence interval ( CI ) 1.32–2.42; P = 0.0002) even in cases of symptomatic irreversible pulpitis ( RR = 1.55; 95% CI 1.05–2.29; P = 0.03). The intensity of pain was lower for ibuprofen (standardised difference means ( SMD ) = −3.73; 95% CI −6.43 to −1.04; P = 0.007). Ibuprofen as premedication is beneficial for the success of inferior alveolar nerve block.