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Animal models used in furcation perforation studies: A systematic review and comprehensive synthesis of model characteristics
Author(s) -
Cardoso Miguel,
Catré Dora,
Noites Rita,
Paulo Manuel,
Viegas Carlos
Publication year - 2018
Publication title -
australian endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 34
eISSN - 1747-4477
pISSN - 1329-1947
DOI - 10.1111/aej.12221
Subject(s) - dentistry , perforation , medicine , animal model , orthodontics , materials science , composite material , punching
In order to systematise furcation perforation (FP) experimental animal models described in the literature and to determine whether there is evidence that a model is superior to others, MEDLINE /PubMed, Sci ELO and Cochrane Library were searched to find studies which used animal models of FP. Data were gathered concerning model characteristics, chosen groups, sample numbers, type of outcomes, journal and main area studied. Twenty‐five articles were included in this systematic review, four conducted in rodent models, three in non‐human primates and 18 in dogs. Medians were six animals and 34 teeth per study; 10 teeth per test group and, when performed, six teeth per control group. Twenty‐four studies investigated the use of materials for FP repair; eight also tested adjuvant materials/substances. Although there is no model which can be described as ideal and superior than others for FP studies, dogs appear to possess the most suitable model characteristics.