Root discolouration following short‐term application of steroid medicaments containing clindamycin, doxycycline or demeclocycline

Discolouration of teeth following application of intra‐canal antibiotic pastes is a clinical concern. This laboratory study compared the extent of tooth discolouration from three antibiotic pastes over 4 weeks. A total of 120 root samples were prepared and the canals filled with either L edermix (demeclocyline), O dontopaste (clindamycin) or DoxyPaste (doxycycline). Roots were photographed before and 2 or 4 weeks after incubation at 37° C and 100% humidity in complete darkness in opaque containers. Digital images were standardised and assessed for changes in luminosity. L edermix paste caused the most discolouration of the three, at both 2 and 4 weeks. There was no significant difference between DoxyPaste and O dontopaste at 2 weeks, whereas at 4 weeks, DoxyPaste caused a greater decrease in luminosity ( P  < 0.05), darkening more over the second 2‐week interval than treatment with O dontopaste ( P  < 0.05). Under zero light conditions, staining with Ledermix can still occur; indicating non‐light‐based chemical reactions in the staining process. Doxycycline containing intra‐canal medicaments caused less staining despite being a tetracycline‐based medicament.