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Comparing the periodontal tissue response to non‐surgical scaling and root planing alone, adjunctive azithromycin, or adjunctive amoxicillin plus metronidazole in generalized chronic moderate‐to‐severe periodontitis: a preliminary randomized controlled trial
Author(s) -
Liaw A,
Miller C,
Nimmo A
Publication year - 2019
Publication title -
australian dental journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 71
eISSN - 1834-7819
pISSN - 0045-0421
DOI - 10.1111/adj.12674
Subject(s) - scaling and root planing , medicine , metronidazole , amoxicillin , azithromycin , adjunctive treatment , periodontitis , antibiotics , chronic periodontitis , aggressive periodontitis , randomized controlled trial , bleeding on probing , dentistry , clinical trial , gastroenterology , microbiology and biotechnology , biology
Background The usefulness of administrating adjunctive systemic antibiotics to expedite healing of periodontal tissues is a topic of interest given the lack of clear guidelines. Aim To compare clinical outcomes in patients given adjunctive azithromycin ( AZ ), adjunctive amoxicillin plus metronidazole ( AMX + MTZ ), or scaling and root planing ( SRP ) alone in the treatment of moderate‐to‐severe chronic periodontitis. Methods Thirty‐eight patients were randomly assigned into: SRP alone; 500 mg AMX plus 400 mg MTZ three times per day for 7 days; or 500 mg AZ for 3 days. Antibiotics were administered after the first SRP session and clinical parameters for full‐mouth and baseline probing pocket depth ( PPD ) categories were reviewed 2‐months post‐treatment. Results Thirty‐four of 38 patients completed the study. All groups experienced significant improvements in full‐mouth clinical attachment level ( CAL ), probing pocket depth ( PPD ) and bleeding on probing. AZ exhibited greater reductions in PPD than SRP alone for baseline severe sites, whilst AMX + MTZ showed significant improvements in PPD and CAL than SRP alone for baseline moderate and severe sites. Of the two antibiotic therapies, AMX + MTZ showed greater reductions in PPD compared with AZ in baseline moderate sites only. Conclusions For patients with moderate‐to‐severe periodontitis, adjunctive systemic antibiotics might result in greater clinical benefits.