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The potential ecological effects of casein phosphopeptide‐amorphous calcium phosphate in dental caries prevention
Author(s) -
Philip N,
Walsh L
Publication year - 2019
Publication title -
australian dental journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 71
eISSN - 1834-7819
pISSN - 0045-0421
DOI - 10.1111/adj.12661
Subject(s) - amorphous calcium phosphate , phosphopeptide , oral microbiome , biofilm , dental plaque , casein , medicine , dysbiosis , dentistry , calcium , microbiome , ecology , chemistry , biochemistry , bioinformatics , biology , phosphorylation , oral cavity , bacteria , genetics
Abstract Contemporary caries prevention protocols recommend not only effective remineralizing agents but also ecological measures to reverse the dental plaque dysbiosis responsible for the disease pathogenesis. There is a high‐level of evidence supporting the remineralizing efficacy of casein phosphopeptide‐amorphous calcium phosphate ( CPP ‐ ACP ) from studies around the world. Evidence is now emerging that CPP ‐ ACP may also have a beneficial influence on the dental plaque microbial ecology and homeostasis. The ecological cariostatic effects of CPP ‐ ACP are believed to be mediated predominantly through its anti‐adhesion, buffering and biofilm disrupting actions. This review principally discusses the ecological mechanisms of CPP ‐ ACP and presents the current evidence for its effects on the oral microbiome ecology.