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Randomized clinical trial of the effects of azithromycin use in the treatment of peri‐implantitis
Author(s) -
Gershenfeld L,
Kalos A,
Whittle T,
Yeung S
Publication year - 2018
Publication title -
australian dental journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 71
eISSN - 1834-7819
pISSN - 0045-0421
DOI - 10.1111/adj.12614
Subject(s) - medicine , peri implantitis , azithromycin , debridement (dental) , randomized controlled trial , mucositis , surgery , soft tissue , placebo , adjunctive treatment , clinical trial , dentistry , bleeding on probing , periodontitis , implant , antibiotics , chemotherapy , pathology , alternative medicine , microbiology and biotechnology , biology
Background The aim of this clinical trial was to establish a proof of concept that the adjunctive use of systemic azithromycin ( AZM ) in conjunction with mechanical debridement has an increased benefit in reducing soft tissue inflammation in the treatment of peri‐implantitis. Methods In a randomized, double‐blind, clinical trial, the treatment group (nine patients) received AZM as well as mechanical debridement in a single course of treatment, whereas the control group (eight patients) received a placebo and mechanical debridement. The primary outcome variables studied were bleeding on probing, suppuration, pocket probing depth and gingival recession. The secondary variables studied were gingival index, plaque index, microbiological and interleukin‐1β status. The observation period was 6 months. Results Over the 6 months’ observation period, the treatment patients showed a consistently greater reduction of gingival inflammation and an improvement in soft tissue healing than the control patients. Conclusions The adjunctive use of a single course of systemic azithromycin can assist in the control of peri‐implant mucositis in the treatment of peri‐implantitis.