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The role of living context in prescription opioid injection and the associated risk of hepatitis C infection
Author(s) -
SacksDavis Rachel,
Daniel Mark,
Roy Élise,
Kestens Yan,
Zang Geng,
Ramos Yuddy,
Hellard Margaret,
Jutras Aswad Didier,
Bruneau Julie
Publication year - 2016
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/add.13470
Subject(s) - medicine , context (archaeology) , hazard ratio , demography , residence , confidence interval , hepatitis c , medical prescription , prospective cohort study , syringe , incidence (geometry) , cohort , proportional hazards model , psychiatry , geography , pharmacology , physics , archaeology , sociology , optics
Background and aims Prescription opioid injection (POI) is a leading risk factor for hepatitis C virus (HCV). Residential context relates to high‐risk injection behaviour. This study assessed whether residence in the inner city (versus surrounding areas in Montréal Island) modified the effects of correlates of POI or the relationship between POI and HCV incidence. Design Prospective cohort study. Setting Montréal, Canada. Participants A total of 854 people who inject drugs (18% female, 25% age < 30 years), living on Montréal Island, were interviewed every 3–6 months from 2004 to 2012. Measurements Study visits included HCV antibody testing and an interviewer‐administered questionnaire. Generalized estimating equations were used to test whether place of residence modified the effects of correlates of POI. Cox regression was used to test whether place of residence modified the relationship between POI and HCV incidence. Findings At baseline, inner‐city participants were more likely to report POI in the past month (40 versus 25%, P < 0.001). The association between POI and heroin injection, syringe sharing and sharing of injecting equipment varied according to place of residence and was greater in the inner city. The hazard of HCV infection associated with POI was greater among inner‐city participants compared to those in the surrounding areas [adjusted hazard ratio (HR) = 3.38, 95% confidence interval (CI) = 1.88–6.07 versus HR = 1.26, 95% CI = 0.65–2.42, P = 0.025]. Conclusions Among people who inject prescription opioids in Montréal, Canada, those who live in inner‐city areas are more likely to engage in injecting‐related risk behaviours and have a higher risk of hepatitis C virus infection than those who live in the suburbs.