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Randomized trial of nicotine replacement therapy ( NRT) , bupropion and NRT plus bupropion for smoking cessation: effectiveness in clinical practice
Author(s) -
Stapleton John,
West Robert,
Hajek Peter,
Wheeler Jenny,
Vangeli Eleni,
Abdi Zeinab,
O'Gara Colin,
McRobbie Hayden,
Humphrey Kirsty,
Ali Rachel,
Strang John,
Sutherland Gay
Publication year - 2013
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/add.12304
Subject(s) - bupropion , nicotine replacement therapy , medicine , smoking cessation , randomized controlled trial , abstinence , odds ratio , nicotine patch , confidence interval , nicotine , varenicline , psychiatry , placebo , alternative medicine , pathology
Background and aims Bupropion was introduced for smoking cessation following a pivotal trial showing that it gave improved efficacy over the nicotine patch and also suggesting combination treatment was beneficial. We tested in clinical practice for an effectiveness difference between bupropion and nicotine replacement therapy ( NRT ), whether the combination improves effectiveness and whether either treatment might be more beneficial for certain subgroups of smokers. Design Open‐label randomized controlled trial with 6‐month follow‐up. Setting Four UK N ational H ealth S ervice ( NHS ) smoking cessation clinics. Participants Smokers ( n = 1071) received seven weekly behavioural support sessions and were randomized to an NRT product of their choice ( n = 418), bupropion ( n = 409) or NRT plus bupropion ( n = 244). Measures The primary outcome was self‐reported cessation over 6 months, with biochemical verification at 1 and 6 months. Also measured were baseline demographics, health history, smoking characteristics and unwanted events during treatment. Findings Abstinence rates for bupropion (27.9%) and NRT (24.2%) were not significantly different (odds ratio = 1.21, 95% confidence interval = 0.883–1.67), and the combination rate (24.2%) was similar to that for either treatment alone. There was some evidence that the relative effectiveness of bupropion and NRT differed according to depression (χ 2 = 2.86, P = 0.091), with bupropion appearing more beneficial than NRT in those with a history of depression (29.8 versus 18.5%). Several unwanted symptoms were more common with bupropion. Conclusion There is no difference in smoking cessation effectiveness among bupropion, nicotine replacement therapy and their combination when used with behavioural support in clinical practice. There is some evidence that bupropion is more beneficial than nicotine replacement therapy for smokers with a history of depression.