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No changes in the oxytocin system in alcohol‐dependent female rodents and humans: Towards a sex‐specific psychopharmacology in alcoholism
Author(s) -
Hansson Anita C.,
Spanagel Rainer
Publication year - 2021
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12945
Subject(s) - oxytocin , oxytocin receptor , alcohol , psychopharmacology , endocrinology , medicine , psychology , neuroscience , psychiatry , biology , biochemistry
A pronounced decrease of oxytocin and increase of oxytocin receptor binding sites were recently reported in male alcohol dependent rats and male alcohol dependent patients. Here we comment on this and emphasize that in female alcohol dependent rats and humans no changes occur in the oxytocin system. We therefore suggest specific intervention with oxytocin only in male subjects.