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The potent psychomotor, rewarding and reinforcing properties of 3‐fluoromethamphetamine in rodents
Author(s) -
Ryu In Soo,
Yoon Seong Shoon,
Choi Mee Jung,
Lee Young Eun,
Kim Ji Sun,
Kim Woo Hyun,
Cheong Jae Hoon,
Kim Hee Jin,
Jang ChoonGon,
Lee Yong Sup,
Steffensen Scott C.,
Ka Minhan,
Woo Dong Ho,
Jang Eun Young,
Seo JoungWook
Publication year - 2020
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12846
Subject(s) - methamphetamine , reinforcement , psychology , conditioned place preference , extinction (optical mineralogy) , self administration , anhedonia , pharmacology , dopaminergic , medicine , striatum , anesthesia , addiction , dopamine , neuroscience , chemistry , social psychology , mineralogy
3‐fluoromethamphetamine (3‐FMA), a derivative of methamphetamine (METH), produces behavioral impairment and deficits in dopaminergic transmission in the striatum of mice. The abuse potential of 3‐FMA has not been fully characterized. The aim of this study was to evaluate the effects of 3‐FMA on locomotor activity as well as its rewarding and reinforcing properties in the conditioned place preference (CPP) and self‐administration procedures. Intravenous (i.v.) administration of 3‐FMA (0.5 and 1.0 mg/kg) significantly increased locomotor activity in a dose‐dependent manner in rats. In the CPP procedure, intraperitoneal administration of 3‐FMA (10 and 30 mg/kg) produced a significant alteration in place preference in mice. In the self‐administration paradigms, 3‐FMA showed drug‐taking behavior at the dose of 0.1 mg/kg/infusion (i.v.) during 2 hr sessions under fixed ratio schedules and high breakpoints at the dose of 0.3 and 1.0 mg/kg/infusion (i.v.) during 6 hr sessions under progressive ratio schedule of reinforcement in rats. A priming injection of 3‐FMA (0.4 mg/kg, i.v.), METH (0.2 mg/kg, i.v.), or cocaine (2.0 mg/kg, i.v.) reinstated 3‐FMA‐seeking behavior after an extinction period in 3‐FMA‐trained rats during 2 hr session. Taken together, these findings demonstrate robust psychomotor, rewarding and reinforcing properties of 3‐FMA, which may underlie its potential for compulsive use in humans.