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Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory
Author(s) -
Gao ShuangQi,
Zhang Hai,
He JinGang,
Zheng HuiLing,
Zhang PeiWei,
Xu JunFeng,
Shen ZuCheng,
Zhao HuanHuan,
Wang Fang,
Hu ZhuangLi,
Chen JianGuo
Publication year - 2020
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12739
Subject(s) - nucleus accumbens , hmgb1 , neuroscience , conditioned place preference , glutamate receptor , addiction , immune system , central nervous system , biology , microbiology and biotechnology , chemistry , pharmacology , receptor , immunology , biochemistry
Cocaine is a common abused drug that can induce abnormal synaptic and immune responses in the central nervous system (CNS). High mobility group box 1 (HMGB1) is one kind of inflammatory molecules that is expressed both on neurons and immune cells. Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown. Here, we show that cocaine exposure induced the translocation and release of HMGB1 in the nucleus accumbens (NAc) neurons. Gain and loss of HMGB1 in the NAc bidirectionally regulate cocaine‐induced conditioned place preference. From the nucleus to the cytosol, HMGB1 binds to glutamate receptor subunits (GluA2/GluN2B) on the membrane, which regulates cocaine‐induced synaptic adaptation and the formation of cocaine‐related memory. These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction.