Premium
Family history of alcoholism is related to increased D 2 /D 3 receptor binding potential: a marker of resilience or risk?
Author(s) -
Alvanzo Anika A. H.,
Wand Gary S.,
Kuwabara Hiroto,
Wong Dean F.,
Xu Xiaoqiang,
McCaul Mary E.
Publication year - 2017
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12300
Subject(s) - family history , raclopride , psychology , radioligand , alcohol use disorder , stimulant , dopamine , medicine , psychiatry , clinical psychology , dopamine receptor d2 , alcohol , receptor , biochemistry , chemistry
The aim of this study was to examine the relationship between family history of alcohol use disorder and striatal dopamine using positron emission tomography imaging. Participants were 84 healthy, 18‐ to 30‐year‐old, social drinkers recruited via fliers and newspaper advertisements. At assessment, participants completed measures of lifetime personal and family substance use and psychiatric symptoms. Participants underwent two consecutive positron emission tomography scans using the D 2 /D 3 dopamine receptor radioligand [ 11 C]raclopride. Scans were preceded by intravenous saline and amphetamine 0.3 mg/kg, providing measures of baseline [ 11 C]raclopride binding potential (BP ND ) and change in [ 11 C]raclopride (ΔBP ND ). Subjective ratings of stimulant drug effects were collected during scans. Subjects were classified as family history positive (FHP) if they reported any first‐degree relative with alcohol use disorder (AUD) and family history negative (FHN) if no first‐degree relatives had history of AUD. Participants were predominantly White (69.0 percent) and male (62.1 percent). Baseline [ 11 C]raclopride BP ND was generally higher in FHP compared with FHN subjects across striatal subdivisions. There were no differences in ΔBP ND across regions. Negative subjective drug effects were more pronounced in FHP than in FHN subjects. While FHN subjects evidenced the expected positive relationship between ΔBP ND and positive subjective drug effects, this relationship was disrupted in FHP subjects. There are key differences in dopamine status and subjective stimulant drug experiences as a function of family AUD history. These findings have important implications for understanding risk for AUD development in FHP offspring.