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Moderate alcohol exposure during early brain development increases stimulus‐response habits in adulthood
Author(s) -
Parker Matthew O.,
Evans Alexandra MD.,
Brock Alistair J.,
Combe Fraser J.,
Teh MuyTeck,
Brennan Caroline H.
Publication year - 2016
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12176
Subject(s) - addiction , psychology , neuroscience , zebrafish , stimulus (psychology) , brain development , developmental psychology , conditioned place preference , affect (linguistics) , biology , biochemistry , gene , psychotherapist , communication
Exposure to alcohol during early central nervous system development has been shown variously to affect aspects of physiological and behavioural development. In extreme cases, this can extend to craniofacial defects, severe developmental delay and mental retardation. At more moderate levels, subtle differences in brain morphology and behaviour have been observed. One clear effect of developmental alcohol exposure is an increase in the propensity to develop alcoholism and other addictions. The mechanisms by which this occurs, however, are not currently understood. In this study, we tested the hypothesis that adult zebrafish chronically exposed to moderate levels of ethanol during early brain ontogenesis would show an increase in conditioned place preference for alcohol and an increased propensity towards habit formation, a key component of drug addiction in humans. We found support for both of these hypotheses and found that the exposed fish had changes in mRNA expression patterns for dopamine receptor, nicotinic acetylcholine receptor and μ‐opioid receptor encoding genes. Collectively, these data show an explicit link between the increased proclivity for addiction and addiction‐related behaviour following exposure to ethanol during early brain development and alterations in the neural circuits underlying habit learning.