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Extinction of a cocaine‐taking context that protects against drug‐primed reinstatement is dependent on the metabotropic glutamate 5 receptor
Author(s) -
Kim Jee Hyun,
Perry Christina,
Luikinga Sophia,
Zbukvic Isabel,
Brown Robyn M.,
Lawrence Andrew J.
Publication year - 2015
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12142
Subject(s) - extinction (optical mineralogy) , context (archaeology) , metabotropic receptor , abstinence , metabotropic glutamate receptor , pharmacology , metabotropic glutamate receptor 5 , psychology , self administration , glutamate receptor , medicine , receptor , chemistry , psychiatry , biology , paleontology , mineralogy
We investigated the effects of extinguishing action‐reward versus context‐reward associations on drug‐primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (m G lu5) in these different types of extinction in rats that self‐administer cocaine. We observed that daily context extinction (non‐reinforced exposures to the cocaine‐taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine‐primed reinstatement compared with passive abstinence. Additionally, systemic injections of the m G lu5 negative allosteric modulator MTEP (3‐[(2‐methyl‐1,3‐thiazol‐4‐yl)ethynyl]‐pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine‐primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.