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Chronic alcohol alters rewarded behaviors and striatal plasticity
Author(s) -
DePoy Lauren,
Daut Rachel,
Wright Tara,
Camp Marguerite,
Crowley Nicole,
Noronha Bianca,
Lovinger David,
Holmes Andrew
Publication year - 2015
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12131
Subject(s) - psychology , neuroscience , alcohol , plasticity , physical medicine and rehabilitation , medicine , biology , materials science , biochemistry , composite material
Chronic intermittent ethanol ( CIE ) alters neural functions and behaviors mediated by the dorsolateral striatum ( DLS ) and prefrontal cortex. Here, we examined the effects of prolonged (16‐bout) CIE on DLS plasticity and DLS ‐mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long‐term depression after CIE . CIE increased two‐bottle choice drinking and impaired Pavlovian‐to‐instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue‐controlled reward‐seeking. Given recent evidence that less‐prolonged CIE can promote certain dorsal striatal‐mediated behaviors, CIE may drive chronicity‐dependent adaptations in corticostriatal systems regulating behavior.