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Overlapping decline in orbitofrontal gray matter volume related to cocaine use and body mass index
Author(s) -
Smith Dana G.,
Jones P. Simon,
Williams Guy B.,
Bullmore Edward T.,
Robbins Trevor W.,
Ersche Karen D.
Publication year - 2015
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12081
Subject(s) - orbitofrontal cortex , body mass index , dysfunctional family , psychology , impulse control , gray (unit) , impulsivity , reward system , addiction , obesity , developmental psychology , clinical psychology , neuroscience , medicine , prefrontal cortex , cognition , radiology
Loss of control over hedonically motivated actions is a defining component of impulse control disorders, such as drug dependence and the proposed ‘food addiction’ model of obesity. Devolution from goal‐directed to compulsively maintained behaviors is partially attributed to abnormalities in the orbitofrontal cortex, an area critical in reward valuation. In the current study, overlapping reductions in orbitofrontal gray matter volume relating to body mass index were seen in healthy control and cocaine‐dependent individuals, as well as in relation to duration of cocaine abuse, providing support for a shared neuropathology between the two conditions potentially related to dysfunctional reward‐seeking behavior.