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Neuropeptide Y Y 2 R blockade in the central amygdala reduces anxiety‐like behavior but not alcohol drinking in alcohol‐dependent rats
Author(s) -
Kallupi Marsida,
Vendruscolo Leandro F.,
Carmichael Casey Y.,
George Olivier,
Koob George F.,
Gilpin Nicholas W.
Publication year - 2014
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12059
Subject(s) - alcohol , autoreceptor , antagonism , neuropeptide , neuropeptide y receptor , amygdala , anxiety , receptor , medicine , endocrinology , chemistry , psychology , antagonist , biochemistry , psychiatry
Electrophysiological data suggest a dual role of Y 2 receptors ( Y 2 R s) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma‐aminobutyric acid release in the central amygdala ( CeA ). Here, we report that neither systemic ( JNJ ‐31020028) nor intra‐ CeA ( BIIE 0246) Y 2 R antagonism altered operant alcohol responding by alcohol‐dependent or non‐dependent rats. Conversely, BIIE 0246 in the CeA reduced anxiety‐like behavior in alcohol‐dependent and alcohol‐naïve rats. The finding that Y 2 R antagonism reduces anxiety‐like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y 2 R (e.g. autoreceptor versus heteroceptor function).