Neuropeptide  Y Y  2  R  blockade in the central amygdala reduces anxiety‐like behavior but not alcohol drinking in alcohol‐dependent rats | Zendy

Kallupi Marsida | Zendy; Vendruscolo Leandro F. | Zendy; Carmichael Casey Y. | Zendy; George Olivier | Zendy; Koob George F. | Zendy; Gilpin Nicholas W. | Zendy

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Neuropeptide Y Y 2 R blockade in the central amygdala reduces anxiety‐like behavior but not alcohol drinking in alcohol‐dependent rats

Author(s) -

Kallupi Marsida,

Vendruscolo Leandro F.,

Carmichael Casey Y.,

George Olivier,

Koob George F.,

Gilpin Nicholas W.

Publication year - 2014

Publication title -

addiction biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.445

H-Index - 78

eISSN - 1369-1600

pISSN - 1355-6215

DOI - 10.1111/adb.12059

Subject(s) - alcohol , autoreceptor , antagonism , neuropeptide , neuropeptide y receptor , amygdala , anxiety , receptor , medicine , endocrinology , chemistry , psychology , antagonist , biochemistry , psychiatry

Electrophysiological data suggest a dual role of Y 2 receptors ( Y 2 R s) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma‐aminobutyric acid release in the central amygdala ( CeA ). Here, we report that neither systemic ( JNJ ‐31020028) nor intra‐ CeA ( BIIE 0246) Y 2 R antagonism altered operant alcohol responding by alcohol‐dependent or non‐dependent rats. Conversely, BIIE 0246 in the CeA reduced anxiety‐like behavior in alcohol‐dependent and alcohol‐naïve rats. The finding that Y 2 R antagonism reduces anxiety‐like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y 2 R (e.g. autoreceptor versus heteroceptor function).

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