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Role of ventral subiculum in context‐induced reinstatement of heroin seeking in rats
Author(s) -
Bossert Jennifer M.,
Stern Anna L.
Publication year - 2014
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/adb.12015
Subject(s) - subiculum , muscimol , context (archaeology) , heroin , baclofen , neuroscience , extinction (optical mineralogy) , psychology , hippocampus , self administration , ventral pallidum , pharmacology , biology , agonist , medicine , drug , central nervous system , basal ganglia , psychiatry , receptor , paleontology , dentate gyrus , globus pallidus
In rats, reexposure to heroin‐paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/ C a1 region plays a critical role in cocaine‐, cue‐ and context‐induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context‐induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior C a1, with the gamma‐aminobutyric acid agonists muscimol + baclofen decreased context‐induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context‐induced relapse across drug classes.