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Low MHC variation in the polar bear: implications in the face of A rctic warming?
Author(s) -
Weber D. S.,
Van Coeverden De Groot P. J.,
Peacock E.,
Schrenzel M. D.,
Perez D. A.,
Thomas S.,
Shelton J. M.,
Else C. K.,
Darby L. L.,
Acosta L.,
Harris C.,
Youngblood J.,
Boag P.,
Desalle R.
Publication year - 2013
Publication title -
animal conservation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.111
H-Index - 85
eISSN - 1469-1795
pISSN - 1367-9430
DOI - 10.1111/acv.12045
Subject(s) - biology , major histocompatibility complex , allele , linkage disequilibrium , haplotype , evolutionary biology , genetic diversity , genetics , disequilibrium , range (aeronautics) , genetic variation , balancing selection , ecology , immune system , gene , population , medicine , materials science , ophthalmology , composite material , demography , sociology
Animals in the A rctic have low pathogen diversity but with rapid climate warming, this is expected to change. One insidious consequence of climate change is exposure of A rctic species to new pathogens derived from more southern species expanding their range northward. To assess potential vulnerability of polar bears to disease exposure, we examined genetic variation in major histocompatibility complex ( MHC ) loci (part of immune system) in C anadian polar bears and found low genetic diversity, consistent with long‐standing exposure to low pathogen/parasite loads. All polar bears surveyed showed maximum linkage disequilibrium between DRB / DQB loci and 12% of individuals had a duplicated DQB gene haplotype. These results may reflect balancing selection at these loci, a response to an earlier immune‐challenge and/or be artifacts of polar bear‐brown bear divergence. Consistent with the latter, we found one DQA allele in polar bears that was also a brown bear DQA allele. The reported low MHC diversity and high linkage disequilibrium may have serious implications for polar bear resistance to new pathogens, which would be maladaptive to species in an environment undergoing rapid climate change, such as the A rctic.