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Reducing the rate of psychiatric re‐admissions in bipolar disorder using smartphones—The RADMIS trial
Author(s) -
FaurholtJepsen Maria,
Lindbjerg Tønning Morten,
Fros Mads,
Martiny Klaus,
Tuxen Nanna,
Rosenberg Nicole,
Busk Jonas,
Winther Ole,
ThaysenPetersen Daniel,
Aamund Kate Andreasson,
Tolderlund Lizzie,
Bardram Jakob Eyvind,
Kessing Lars Vedel
Publication year - 2021
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.13274
Subject(s) - medicine , randomized controlled trial , hazard ratio , bipolar disorder , depression (economics) , young mania rating scale , rating scale , psychiatry , brief psychiatric rating scale , mania , confidence interval , psychology , mood , developmental psychology , psychosis , economics , macroeconomics
Objectives The MONARCA I and II trials were negative but suggested that smartphone‐based monitoring may increase quality of life and reduce perceived stress in bipolar disorder (BD). The present trial was the first to investigate the effect of smartphone‐based monitoring on the rate and duration of readmissions in BD. Methods This was a randomized controlled single‐blind parallel‐group trial. Patients with BD (ICD‐10) discharged from hospitalization in the Mental Health Services, Capital Region of Denmark were randomized 1:1 to daily smartphone‐based monitoring including a feedback loop (+ standard treatment) or to standard treatment for 6 months. Primary outcomes: the rate and duration of psychiatric readmissions. Results We included 98 patients with BD. In ITT analyses, there was no statistically significant difference in rates (hazard rate: 1.05, 95% CI: 0.54; 1.91, p = 0.88) or duration of readmission between the two groups (B: 3.67, 95% CI: −4.77; 12.11, p = 0.39). There was no difference in scores on the Hamilton Depression Rating Scale (B = −0.11, 95% CI: −2.50; 2.29, p = 0.93). The intervention group had higher scores on the Young Mania Rating Scale (B: 1.89, 95% CI: 0.0078; 3.78, p = 0.050). The intervention group reported lower levels of perceived stress (B: ‐7.18, 95% CI: −13.50; −0.86, p = 0.026) and lower levels of rumination (B: −6.09, 95% CI: −11.19; −1.00, p = 0.019). Conclusions Smartphone‐based monitoring did not reduce rate and duration of readmissions. There was no difference in levels of depressive symptoms. The intervention group had higher levels of manic symptoms, but lower perceived stress and rumination compared with the control group.