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A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder
Author(s) -
Hui T. P.,
Kandola A.,
Shen L.,
Lewis G.,
Osborn D. P. J.,
Geddes J. R.,
Hayes J. F.
Publication year - 2019
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.13062
Subject(s) - bipolar disorder , lithium (medication) , meta analysis , psychology , clinical psychology , psychiatry , medicine
Objective To determine clinical predictors of lithium response in bipolar disorder. Methods Systematic review of studies examining clinical predictors of lithium response was conducted. Meta‐analyses were performed when ≥2 studies examined the same potential predictor. Results A total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania‐depression‐interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P  < 0.001], absence of rapid cycling (OR for rapid cycling: 0.30; 95% CI: 0.17, 0.53; P  < 0.001), absence of psychotic symptoms (OR for psychotic symptoms: 0.52; 95% CI: 0.34, 0.79; P  = 0.002), family history of bipolar disorder (OR: 1.61; 95% CI: 1.03, 2.52; P  = 0.036), shorter prelithium illness duration [standardised mean difference (SMD): −0.26; 95% CI: −0.41, −0.12; P  < 0.001] and later age of onset (SMD: 0.17; 95% CI: 0.02, 0.36; P  = 0.029). Additionally, higher body mass index was associated with poor response in two studies (SMD: −0.61; 95% CI: −0.90, −0.32; P  < 0.001). There was weak evidence for number of episodes prior to lithium treatment (SMD: −0.42; 95% CI: −0.84, −0.01; P  = 0.046), number of hospitalisations before lithium (SMD: −0.40; 95% CI: −0.81, 0.01; P  = 0.055) and family history of lithium response (OR: 10.28; 95% CI: 0.66, 161.26; P  = 0.097). Conclusions The relative importance of these clinical characteristics should be interpreted with caution because of potential biases and confounding.

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