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Association of intracortical myelin and cognitive function in bipolar I disorder
Author(s) -
Sehmbi M.,
Rowley C. D.,
Minuzzi L.,
Kapczinski F.,
Steiner M.,
Sassi R. B.,
Bock N. A.,
Frey B. N.
Publication year - 2018
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12875
Subject(s) - cognition , bipolar disorder , neuroscience , psychology , association (psychology) , prefrontal cortex , audiology , medicine , psychotherapist
Objective Although cognitive dysfunction persists through affective and euthymic states in bipolar disorder ( BD ), its neurobiological correlates remain undetermined. We explore whole‐cortex intracortical myelin ( ICM ) and cognition in BD ‐I and controls. Methods T 1 ‐weighted images (3T) optimized for ICM measurement were analyzed using a surface‐based approach. MRI signal was sampled at cortical mid‐depth. Cognitive performance was measured via standardized computerized battery and paper‐and‐pencil Trails B. Results ICM was associated with verbal memory ( VM ) in BD throughout a cortical network identified with pertinence to VM function, with strongest effects in left caudal middle temporal cortex and left dorsolateral prefrontal cortex ( P corrected < 0.05). Subanalyses revealed specific association with correct word recognition, without delay. Processing speed, executive function, and reaction time were also predicted by ICM in BD , but not controls, although this did not survive Bonferroni correction. Conclusion This is the first study to show VM association with ICM in BD . ICM has been implicated in the integrity of neural connections and neural synchrony. VM dysfunction is one of the most replicated cognitive abnormalities in BD . Therefore, these results provide a novel mechanism for understanding cognitive dysfunction in BD , which can aid in the development of targeted therapeutics to improve cognitive outcomes in BD .