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No cognitive‐enhancing effect of GLP ‐1 receptor agonism in antipsychotic‐treated, obese patients with schizophrenia
Author(s) -
Ishøy P. L.,
Fagerlund B.,
Broberg B. V.,
Bak N.,
Knop F. K.,
Glenthøj B. Y.,
Ebdrup B. H.
Publication year - 2017
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12711
Subject(s) - schizophrenia (object oriented programming) , positive and negative syndrome scale , exenatide , antipsychotic , psychosocial , psychology , placebo , medicine , repeated measures design , cognition , psychiatry , type 2 diabetes , psychosis , endocrinology , diabetes mellitus , statistics , alternative medicine , mathematics , pathology
Objective Schizophrenia is associated with profound cognitive and psychosocial impairments. Glucagon‐like peptide‐1 receptor agonists ( GLP ‐1 RA s) are used for diabetes and obesity treatment, and animal studies have indicated cognitive‐enhancing effects. In this investigator‐initiated, double‐blind, randomized, placebo‐controlled trial, we tested non‐metabolic effects of exenatide once‐weekly (Bydureon™) in obese, antipsychotic‐treated patients with schizohrenia spectrum disorder. Method Before and after 3 months of exenatide ( N = 20) or placebo ( N = 20) treatment, patients were assessed with the following: Brief Assessment of Cognition in Schizophrenia ( BACS ), Rey–Osterreith complex figure test ( REY ), Short‐Form Health Survey ( SF ‐36), Personal and Social Performance Scale ( PSP ) and the Positive and Negative Syndrome Scale ( PANSS ). We used BACS composite score as the main outcome measure. Results Repeated measures analysis of variance on BACS composite score showed significant effect of ‘Time’ ( P < 0.001), no effect of ‘Group’ ( P = 0.64) and no ‘Time*Group’ interaction ( P = 0.77). For REY , SF ‐36, PSP and PANSS , only significant ‘Time’ effects were found. Conclusion The non‐significant results of this first clinical trial exploring non‐metabolic effects of a long‐acting GLP ‐1 RA in patients with schizophrenia could reflect a general problem of translating cognitive‐enhancing effects of GLP ‐1 RA s from animals to humans or be explained by factors specifically related to schizophrenia spectrum patients with obesity such as antipsychotic treatment.