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CSF YKL‐40 and GAP‐43 are related to suicidal ideation in older women
Author(s) -
Rymo I.,
Kern S.,
Bjerke M.,
Zetterberg H.,
Marlow T.,
Blennow K.,
Gudmundsson P.,
Skoog I.,
Waern M.
Publication year - 2017
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12701
Subject(s) - suicidal ideation , medicine , depression (economics) , cerebrospinal fluid , prospective cohort study , etiology , clinical psychology , psychology , psychiatry , gastroenterology , poison control , injury prevention , environmental health , economics , macroeconomics
Objective To investigate possible relationships between suicidal ideation and cerebrospinal fluid ( CSF ) levels of glial markers YKL ‐40 (also known as chitinase‐3‐like protein 1), growth‐associated protein‐43 ( GAP ‐43) and myelin basic protein ( MBP ). Method The sample was obtained from the Prospective Population Study of Women and included 86 women without dementia who underwent both psychiatric examinations and lumbar puncture ( LP ). Eight of these women reported past‐month suicidal ideation. Results Significantly, higher CSF levels of both YKL ‐40 and GAP ‐43 were detected in women with past‐month suicidal ideation. Associations with suicidal ideation remained for both YKL ‐40 and GAP ‐43 in regression models adjusted for smoking status, BMI and age. CSF levels of YKL ‐40, GAP ‐43 and MBP did not differ by depression status. Higher levels of CSF GAP ‐43 were associated with feelings of worthlessness; a strong relationship was demonstrated in the fully adjusted model ( OR 5.95 CI [1.52–23.20], P = 0.01). Conclusion Our findings of elevated CSF concentrations of both YKL ‐40 and GAP ‐43 in women with suicidal ideation, compared to those without, suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.