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Abnormal functional–structural cingulum connectivity in mania: combined functional magnetic resonance imaging‐diffusion tensor imaging investigation in different phases of bipolar disorder
Author(s) -
Martino M.,
Magioncalda P.,
Saiote C.,
Conio B.,
Escelsior A.,
Rocchi G.,
Piaggio N.,
Marozzi V.,
Huang Z.,
Ferri F.,
Amore M.,
Inglese M.,
Northoff G.
Publication year - 2016
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12596
Subject(s) - cingulum (brain) , diffusion mri , neurocognitive , fractional anisotropy , psychology , magnetic resonance imaging , functional magnetic resonance imaging , bipolar disorder , mania , neuroscience , medicine , radiology , cognition
Objective The objective of the study was to investigate the relationship between structural connectivity ( SC ) and functional connectivity ( FC ) in the cingulum in bipolar disorder ( BD ) and its various phases. Method We combined resting‐state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate FC and SC of the cingulum and its portions, the SC – FC relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic ( n = 21), depressed ( n = 20), and euthymic ( n = 20) bipolar patients and healthy controls ( HC ) ( n = 42). Results First, we found decreased FC between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and HC . Second, we observed decreased SC of the cingulum bundle, particularly in its anterior part, in manic patients when compared to HC . Finally, alterations in the cingulum FC (but not SC ) correlated with clinical severity scores while changes in the cingulum SC (but not FC ) were related with neurocognitive deficits in sustained attention in BD . Conclusion We demonstrate for the first time a reduction in FC and concomitantly in SC of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in BD . This supports the central role of cingulum connectivity specifically in mania.