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Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion
Author(s) -
Biskup C. S.,
Helmbold K.,
Baurmann D.,
Klasen M.,
Gaber T. J.,
BubenzerBusch S.,
Königschulte W.,
Fink G. R.,
Zepf F. D.
Publication year - 2016
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12573
Subject(s) - default mode network , serotonergic , psychology , resting state fmri , somatosensory system , serotonin , neuroscience , neurotransmitter , medicine , functional magnetic resonance imaging , central nervous system , receptor
Objective Alterations of the default mode network ( DMN ) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder ( ADHD ), and the neurotransmitter serotonin (5‐ HT ) is known to modulate DMN activity. This study aimed to explore the role of 5‐ HT on the DMN and its functional connectivity ( FC ) in young patients with ADHD . Methods Young male patients with ADHD ( n = 12) and healthy controls ( n = 10) (both aged 12–17 years) were subjected to acute tryptophan depletion ( ATD ) and subsequently diminished brain 5‐ HT synthesis. Three hours after challenge intake ( ATD or a balanced control condition, BAL ), resting state fMRI scans were obtained. Results In patients, ATD led to attenuated FC of the right superior premotor cortex ( BA 6) with the DMN , comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex ( BA 3) with the DMN , independently of the factor group, but with stronger effects in controls. Conclusions Data reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN , thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD .