Premium
Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Author(s) -
Cunha G. R.,
Asevedo E.,
Mansur R. B.,
Zugman A.,
Pan P. M.,
Gadelha A.,
Belangero S. I.,
Rizzo L. B.,
Coelho R.,
Stertz L.,
CogoMoreira H.,
GrassiOliveira R.,
Teixeira A. L.,
KauerSant'Anna M.,
Mari J. J.,
Miguel E. C.,
Bressan R. A.,
Brietzke E.
Publication year - 2016
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12453
Subject(s) - psychopathology , cbcl , medicine , clinical psychology , biomarker , psychology , psychiatry , biochemistry , chemistry
Objective To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method A total of 625 aged 6‐ to 13‐year old subjects were recruited from a community school‐based study. Psychopathology was assessed using the Child Behaviour Checklist ( CBCL ). Psychiatric diagnosis was evaluated using the Development and Well‐Being Assessment. The following biomarkers were examined in peripheral blood: brain‐derived neurotrophic factor, cytokines ( IL ‐2, IL ‐4, IL ‐6, IL ‐10, IL ‐17, IFN ‐g, and TNF ‐α), chemokines (eotaxin/ CCL 11, IP ‐10, MCP ‐1), cytokine receptors ( sTNFR 1 and sTNFR 2), and the oxidative stress marker TBARS. Results We found significant associations between sTNFR 2, eotaxin/ CCL 11 and CBCL total score, as well as with specific dimensions of psychopathology. There were different patterns of association between these biomarkers and psychological and behavioural symptoms in children with and without a mental disorder. TBARS , IL ‐6 and MCP ‐1 were more specific to some clusters of symptoms in children with a psychiatric diagnosis. Conclusion Our data support the potential use of biomarkers, especially those involved in immune–inflammatory pathways, in investigating neurodevelopmental psychopathology. Their association with different dimensions of symptoms might be of useful when analyzing illness severity and clusters of symptoms within specific disorders.