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Intrinsic Connectivity Networks in post‐traumatic stress disorder during sub‐ and supraliminal processing of threat‐related stimuli
Author(s) -
Rabellino D.,
Tursich M.,
Frewen P. A.,
Daniels J. K.,
Densmore M.,
Théberge J.,
Lanius R. A.
Publication year - 2015
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12418
Subject(s) - subliminal stimuli , default mode network , psychology , precuneus , neuroscience , amygdala , functional magnetic resonance imaging , anterior cingulate cortex , consciousness , prefrontal cortex , cognition , audiology , cognitive psychology , medicine
Abstract Objective To investigate the functional connectivity of large‐scale intrinsic connectivity networks ( ICN s) in post‐traumatic stress disorder ( PTSD ) during subliminal and supraliminal presentation of threat‐related stimuli. Method Group independent component analysis was utilized to study functional connectivity within the ICN s most correlated with the Default‐mode Network ( DMN ), Salience Network ( SN ), and Central Executive Network ( CEN ) in PTSD participants ( n = 26) as compared to healthy controls ( n = 20) during sub‐ and supraliminal processing of threat‐related stimuli. Results Comparing patients with PTSD with healthy participants, prefrontal and anterior cingulate cortex involved in top‐down regulation showed increased integration during subliminal threat processing within the CEN and SN and during supraliminal threat processing within the DMN . The right amygdala showed increased connectivity with the DMN during subliminal processing in PTSD as compared to controls. Brain regions associated with self‐awareness and consciousness exhibited decreased connectivity during subliminal threat processing in PTSD as compared to controls: the claustrum within the SN and the precuneus within the DMN . Conclusion Key nodes of the ICN s showed altered functional connectivity in PTSD as compared to controls, and differential results characterized sub‐ and supraliminal processing of threat‐related stimuli. These findings enhance our understanding of ICN s underlying PTSD at different levels of conscious threat perception.