Premium
Brain‐derived neurotrophic factor and inflammatory markers in school‐aged children with early trauma
Author(s) -
Bücker J.,
Fries G. R.,
Kapczinski F.,
Post R. M.,
Yatham L. N.,
Vianna P.,
Bogo Chies J. A.,
Gama C. S.,
Magalhães P. V.,
Aguiar B. W.,
Pfaffenseller B.,
KauerSant'Anna M.
Publication year - 2015
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12358
Subject(s) - proinflammatory cytokine , medicine , neurotrophic factors , brain derived neurotrophic factor , tumor necrosis factor alpha , inflammation , endocrinology , receptor
Objective The impact of childhood trauma ( CT ) on brain‐derived neurotrophic factor ( BDNF ) and cytokines levels remains unclear. We investigated the association between CT and changes in BDNF and cytokines plasma levels in children. Method We recruited 36 children with trauma ( CT +) and 26 children without trauma ( CT ‐). The presence of CT was based on a clinical interview and by Criteria A of DSM ‐ IV criteria for PTSD . Blood samples were drawn from all children to assess BDNF and cytokines. ancova was performed with psychiatric symptoms and BMI as covariates to evaluate group differences in plasma levels. Results CT + showed increased levels of BDNF and TNF ‐α after excluding children with history of inflammatory disease ( P < 0.05) when compared with those CT ‐. IL ‐12p70, IL ‐6, IL ‐8, IL ‐10, and IL ‐1β levels were not statistically different between groups. Conclusion CT + showed increased BDNF and proinflammatory cytokines levels. The increase in BDNF levels may be an attempt to neutralize the negative effects of CT , while an increase in TNF ‐a levels be associated with a proinflammatory state after CT . How these changes associated with trauma relate to other biological changes and illness trajectory later in life remain to be further studied.