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Resting‐state connectivity deficits associated with impaired inhibitory control in non‐treatment‐seeking adolescents with psychotic symptoms
Author(s) -
Jacobson McEwen S. C.,
Connolly C. G.,
Kelly A. M. C.,
Kelleher I.,
O'Hanlon E.,
Clarke M.,
Blanchard M.,
McNamara S.,
Connor D.,
Sheehan E.,
Donohoe G.,
Can M.,
Garavan H.
Publication year - 2014
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12141
Subject(s) - precuneus , inferior frontal gyrus , psychosis , resting state fmri , psychology , medial frontal gyrus , functional magnetic resonance imaging , psychiatry , psychopathology , schizophrenia (object oriented programming) , neuroscience , clinical psychology
Objective Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who reported psychotic symptoms (the extended psychosis phenotype). Method This study investigated intrinsic functional connectivity (i FC ) during resting‐state functional magnetic resonance imaging (f MRI ; rs‐f MRI ). Following screening in schools, 11 non‐treatment seeking, youth with psychotic symptoms (aged 11–13) and 14 community controls participated in the study. Seed regions of interest comprised brain regions previously shown to exhibit aberrant activation during inhibitory control in adolescents with psychotic symptoms. Results Relative to controls, adolescents with psychotic symptoms exhibited reduced i FC between regions supporting inhibitory control. Specifically, they showed weaker i FC between the right inferior frontal gyrus ( IFG ) and the cingulate, IFG and the striatum, anterior cingulate and claustrum, and precuneus and supramarginal gyrus. Conversely, the psychotic symptoms group exhibited stronger i FC between the superior frontal gyrus and claustrum and IFG and lingual gyrus. Conclusion The present findings are the first to reveal aberrant functional connectivity in resting‐state networks in a community sample of adolescents with psychotic symptoms and suggest that disruption in integration between distributed neural networks (particularly between prefrontal, cingulate and striatal brain regions) may be a key neurobiological feature of the extended psychosis phenotype.