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A randomized controlled trial of mindfulness‐based cognitive therapy for bipolar disorder
Author(s) -
Perich T.,
Manicavasagar V.,
Mitchell P. B.,
Ball J. R.,
HadziPavlovic D.
Publication year - 2013
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/acps.12033
Subject(s) - young mania rating scale , bipolar disorder , psychology , mania , anxiety , mindfulness , randomized controlled trial , mindfulness based cognitive therapy , mood , psychiatry , clinical psychology , rating scale , depression (economics) , cognitive therapy , cognition , medicine , developmental psychology , economics , macroeconomics
Objective To compare the efficacy of mindfulness‐based cognitive therapy ( MBCT ) plus treatment as usual ( TAU ) to TAU alone for patients with bipolar disorder over a 12‐month follow‐up period. Method Participants with a DSM ‐ IV diagnosis of bipolar disorder were randomly allocated to either MBCT plus TAU or TAU alone. Primary outcome measures were time to recurrence of a DSM ‐ IV major depressive, hypomanic or manic episode; the M ontgomery‐ Å sberg D epression R ating S cale ( MADRS ); and Y oung M ania R ating S cale ( YMRS ). Secondary outcome measures were number of recurrences, the D epression A nxiety S tress S cales ( DASS ), and the S tate T rait A nxiety I nventory ( STAI ). Results Ninety‐five participants with bipolar disorder were recruited to the study ( MBCT = 48; TAU = 47). Intention‐to‐treat ( ITT ) analysis found no significant differences between the groups on either time to first recurrence of a mood episode or total number of recurrences over the 12‐month period. Furthermore, there were no significant between‐group differences on the MADRS or YMRS scales. A significant between‐group difference was found in STAI – state anxiety scores. There was a significant treatment by time interaction for the DAS – achievement subscale. Conclusion While MBCT did not lead to significant reductions in time to depressive or hypo/manic relapse, total number of episodes, or mood symptom severity at 12‐month follow‐up, there was some evidence for an effect on anxiety symptoms. This finding suggests a potential role of MBCT in reducing anxiety comorbid with bipolar disorder.