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Mitochondrial Dysfunction of Human Muscle in Chronic Alcoholism Detected by Using 31 P‐Magnetic Resonance Spectroscopy and Near‐Infrared Light Absorption
Author(s) -
Haida Munetaka,
Yazaki Koji,
Kurita Daisaku,
Shinohara Yukito
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.1998.22.s3_part1.108s
Subject(s) - anaerobic exercise , medicine , intracellular ph , metabolism , endocrinology , chemistry , nuclear magnetic resonance , biochemistry , intracellular , physiology , physics
We previously examined the effect of alcohol on muscle energy metabolism in chronic alcoholics by using 31 P‐magnetic resonance spectroscopy. Measurements of intracellular pH and PCr index [PCr/(PCr + Pi)] during resting, hand grasping, and recovery in the left flexor digitorum superficialis muscle of alcoholics with neurological signs showed a marked decrease and delayed recovery of pH, but rapid recovery of PCr index indicating that the muscle produces lactate during and after exercise to maintain the ATP level. To clarify the reason for this preference for anaerobic metabolism, we conducted simultaneous measurements of the muscle blood supply during and after exercise by using the near‐infrared light method and energy metabolism by using 31 P‐magnetic resonance spectroscopy. In alcoholics with neurological signs, we observed a significant increase of oxyhemoglobin after exercise with a slight increase of total hemoglobin. In healthy volunteers and chronic alcoholics without neurological signs, such an overshoot of oxyhemoglobin was not observed. We conclude that chronic alcoholics with neurological signs have an abnormality of aerobic metabolism owing to muscle mitochondrial dysfunction.