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Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers
Author(s) -
DeMartini Kelly S.,
Gueorguieva Ralitza,
Pearlson Godfrey,
KrishnanSarin Suchitra,
Anticevic Alan,
Ji Lisa J.,
Krystal John H.,
O’Malley Stephanie S.
Publication year - 2021
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.14580
Subject(s) - psychology , impulsivity , neglect , addiction , structural equation modeling , alcohol use disorder , clinical psychology , confirmatory factor analysis , developmental psychology , psychiatry , alcohol , biochemistry , statistics , chemistry , mathematics
Objective Recent studies have examined the factor structure and associated correlates of three neurofunctional domains, executive function, incentive salience, and negative emotionality in the development and maintenance of alcohol use disorders in clinical samples. The current study sought to replicate and extend prior work by testing this 3‐factor model, utilizing both exact and similar phenotypic measures, as well as novel measures, in a non–treatment‐seeking sample. Methods Self‐report measures of alcohol addiction, impulsivity, behavior, and exposure to early‐life stress were collected as part of baseline assessments for alcohol imaging and pharmacotherapy studies in 335 individuals. Confirmatory factor analysis (CFA) was used to examine model structure and fit. A multiple indicators, multiple causes (MIMIC) model identified predictors of latent factors identified by CFA. Results Results supported an intercorrelated model with three factors: executive function, incentive salience, and emotionality. All factors were associated with current AUD, and incentive salience was uniquely associated with past 30‐day drinking frequency. MIMIC results identified multiple significant predictors of these latent factors, including history of alcohol use disorder, positive family history of alcohol dependence, earlier age of first drink, and a history of childhood emotional abuse and physical neglect. Conclusions Our results support an intercorrelated 3‐factor model of neurofunctional domains in alcohol use models, consistent with published findings. Because childhood physical neglect was a significant predictor of all latent factors, these results also highlight the significant negative impact of childhood neglect on later addiction development.