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Association Between the Aldehyde Dehydrogenase‐2 rs671 G>A Polymorphism and Head and Neck Cancer Susceptibility: A Meta‐Analysis in East Asians
Author(s) -
Du XinYa,
Wen Li,
Hu YuanYuan,
Deng ShengQiong,
Xie LongChuan,
Jiang GuangBin,
Yang GongLi,
Niu YuMing
Publication year - 2021
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.14527
Subject(s) - aldh2 , meta analysis , odds ratio , publication bias , confidence interval , medicine , aldehyde dehydrogenase , genetics , oncology , biology , gene
Background Aldehyde dehydrogenase‐2 (ALDH2) plays an important role in the alcohol detoxification and acetaldehyde metabolism. Published studies have demonstrated some inconsistent associations between ALDH2 rs671 G>A polymorphism and head and neck cancer (HNC) risk. Methods A meta‐analysis was performed to provide pooled data on the association between the ALDH2 rs671 G>A polymorphism and HNC risk. Electronic databases were searched to identify relevant studies. Odds ratios and 95% confidence intervals (CIs) were used to examine the pooled effect size of each genetic model. In addition, heterogeneity test, accumulative analysis, sensitivity analysis, and publication bias were conducted to test the statistical power. Results Thirteen publications (14 independent case–control studies) involving 10,939 subjects were selected. The stratified analysis indicated that both light/moderated drinking (e.g., GA vs. GG: OR = 1.47, 95% CI = 1.16 to 1.86, p < 0.01, I 2 = 81.1%) and heavy drinking would increase HNC risk with rs671 G>A mutation (e.g., GA vs. GG: OR = 2.30, 95% CI = 1.11 to 4.77, p = 0.03, I 2 = 81.9%). Conclusions In summary, this meta‐analysis suggested that the ALDH2 rs671 G>A polymorphism may play an important synergistic effect in the pathogenesis of HNC development in East Asians.