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A 22‐Year Follow‐Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism
Author(s) -
Schuckit Marc A.,
Smith Tom L.,
Danko George,
Kramer John,
Bucholz Kathleen K.,
McCutcheon Vivia,
Chan Grace,
Kuperman Samuel,
Hesselbrock Victor,
Dick Danielle M.,
Hesselbrock Michie,
Porjesz Bernice,
Edenberg Howard J.,
Nureberger John I.,
Gregg Marcy,
Schoen Lara,
Kawamura Mari,
Mendoza Lee Anne
Publication year - 2018
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.13810
Subject(s) - baseline (sea) , alcohol use disorder , medicine , alcohol , medical genetics , psychiatry , psychology , genetics , biology , biochemistry , fishery , gene
Background Recent reports indicate higher‐than‐expected problematic drinking in older populations. However, few data describe how to predict which older individuals are most likely to demonstrate alcohol‐related problems, including those with earlier alcohol use disorders ( AUD s). These analyses evaluate predictors of alcohol outcomes in individuals with earlier AUD s in the Collaborative Study on Genetics of Alcoholism ( COGA ). Methods Original COGA participants with baseline AUD s at about age 40 were interviewed 13 to 26 years later and placed into clinically derived outcome categories. Chi‐square and analysis of variance evaluated baseline differences across 4 outcome groups, with significant items entered into binary logistic regression backwards elimination analyses predicting outcomes. Results Low‐Risk Drinkers ( N = 100) at follow‐up were predicted by baseline higher levels of response to alcohol (high LR s), lower histories of alcohol treatment, experience with fewer types of illicit drugs, and were more likely to have been widowed. At follow‐up, Problem Drinkers ( N = 192) differed from High‐Risk Drinkers ( N = 93) who denied multiple alcohol problems by exhibiting baseline lower LR s, higher Sensation Seeking, and a higher proportion who were widowed. Abstinent ( N = 278) outcomes were predicted by a history of higher baseline AUD treatments, higher alcohol problems, lower usual drinks, as well as older age and European American heritage. Thirty‐four subjects (4.9%) could not be classified and were not included in these analyses. Conclusions These results generated from AUD individuals from both treatment and nontreatment settings reinforce low probabilities of recent Low‐Risk Drinking in individuals with AUD s, but also suggest many individuals with AUD s demonstrate good outcomes 2 decades later.