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Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury
Author(s) -
Davis Booker T.,
Voigt Robin M.,
Shaikh Maliha,
Forsyth Christopher B.,
Keshavarzian Ali
Publication year - 2018
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.13612
Subject(s) - circadian rhythm , alcohol consumption , alcohol , addiction , alcohol tolerance , alcohol use disorder , alcohol and health , alcohol intake , psychology , neuroscience , physiology , medicine , biology , biochemistry
Heavy use of alcohol can lead to addictive behaviors and to eventual alcohol‐related tissue damage. While increased consumption of alcohol has been attributed to various factors including level of alcohol exposure and environmental factors such as stress, data from behavioral scientists and physiological researchers are revealing roles for the circadian rhythm in mediating the development of behaviors associated with alcohol use disorder as well as the tissue damage that drives physiological disease. In this work, we compile recent work on the complex mutually influential relationship that exists between the core circadian rhythm and the pharmacodynamics of alcohol. As we do so, we highlight implications of the relationship between alcohol and common circadian mechanisms of effected organs on alcohol consumption, metabolism, toxicity, and pathology.