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Alcohol Intake During Pregnancy and Offspring's Atopic Eczema Risk
Author(s) -
Wada Keiko,
Konishi Kie,
Tamura Takashi,
Shiraki Makoto,
Iwasa Shinichi,
Nagata Chisato
Publication year - 2016
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.13048
Subject(s) - medicine , asthma , pregnancy , allergy , food allergy , atopy , pediatrics , offspring , cohort study , cohort , obstetrics , immunology , genetics , biology
Background Although alcohol consumption has been suggested to have an effect on the immune system, it is unknown whether alcohol consumption has a role in developing allergic diseases. We aimed to examine the associations of total alcohol intake during pregnancy with the risks of childhood asthma and atopic eczema in a birth cohort in Japan. Methods Pregnant women were recruited at a maternal clinic from May 2000 to October 2001. The children who were born to these mothers were followed until November 2007. Total alcohol intake, including alcohol as a cooking ingredient, was assessed using 5‐day dietary records. Mother reports of physician‐diagnosed asthma and atopic eczema were annually obtained from the questionnaires. Asthma assessed by the American Thoracic Society Division of Lung Diseases questionnaire and atopic eczema assessed by International Study of Asthma and Allergies in Childhood questions were also obtained in 2007. A total of 350 children participated in the follow‐up survey. Results Maternal total alcohol intake during pregnancy was associated with increased risks of atopic eczema before age 3. The positive association with atopic eczema was also observed when it was defined as before age 5. In the high versus the low tertile of maternal total alcohol intake, the estimated hazard ratios (HRs) of child's eczema were 1.90 (95% CI : 0.96 to 3.76) before age 3 and 1.74 (95% CI : 0.93 to 3.24) before age 5, respectively. The estimated HRs of child's asthma before age 3 was 1.61 (95% CI : 0.70 to 3.69) in the high versus the low of maternal total alcohol intake and 2.11 (95% CI : 0.93 to 4.81) among children having drinking mothers versus nondrinking mothers in pregnancy, although maternal alcohol intake during pregnancy was not significantly associated with the risk of asthma before age 5. Conclusions Alcohol consumption during pregnancy might have an effect on developing atopic eczema in offspring.