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Varenicline for Treatment of Alcohol Dependence: A Randomized, Placebo‐Controlled Trial
Author(s) -
Bejczy Andrea,
Löf Elin,
Walther Lisa,
Guterstam Joar,
Hammarberg Anders,
Asanovska Gulber,
Franck Johan,
Isaksson Anders,
Söderpalm Bo
Publication year - 2015
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.12854
Subject(s) - varenicline , placebo , alcohol use disorders identification test , medicine , craving , alcohol dependence , population , partial agonist , randomized controlled trial , alcohol consumption , alcohol , psychiatry , agonist , nicotine , addiction , chemistry , biochemistry , environmental health , receptor , pathology , alternative medicine
Background Alcohol dependence is a devastating illness affecting a large population, and new pharmacological treatments with good efficacy are greatly needed. One potential candidate is varenicline, a smoking cessation agent with partial agonist action at α 4 β 2 nicotinic acetylcholine receptors. Methods A total of 160 subjects, 30 to 70 years of age, fulfilling DSM ‐ IV criteria for alcohol dependence without any serious physical or mental disorders, were recruited through advertisement at 3 university clinics in Sweden during March 2009 to January 2011. After a 2‐week placebo run‐in period, subjects received 2 mg varenicline daily (titrated from 0.5 mg during first week) or placebo for 12 weeks in a double‐blind manner. Results The primary outcome was the proportion of heavy drinking days, measured by self‐reported alcohol consumption. Primary and secondary outcomes were calculated as a mean over the 10‐week steady‐state active treatment period. In the primary outcome analysis, no effect of varenicline over placebo was found ( p = 0.73 for the intention to treat [ ITT ] and 0.92 for per protocol [ PP ]). Secondary outcome analysis found a significant reduction of specific alcohol marker phosphatidylethanol ( PE th) in the blood in the varenicline group compared to placebo ( p = 0.02 ITT ). Craving ( p = 0.048 PP ) and Alcohol Use Disorders Identification Test ( AUDIT ) scores ( p = 0.015 ITT ) were also reduced in the active treatment group. PE th more strongly correlated with self‐reported alcohol consumption than carbohydrate‐deficient ttransferrin and γ ‐glutamyl transferase, and correlation coefficients were higher in the varenicline group than in the placebo group for all markers. Conclusions Although the results of the main outcome of this study did not support an effect of varenicline in alcohol‐dependent individuals, the secondary analyses of PE th, craving and AUDIT score support an effect of varenicline on alcohol consumption. The disclosure of a treatment effect and the lack of a clear placebo effect when using PE th as outcome variable, together with a nonsymmetric bias associated with self‐reported data, strongly argue for using the specific biomarker PE th in studies of treatments of alcohol dependence.